WEBVTT

00:00:07.480 --> 00:00:12.000
Benign prostatic hyperplasia
is a significant health issue

00:00:12.080 --> 00:00:13.600
for men across the globe.

00:00:14.560 --> 00:00:18.960
As men age, the prostate gland often
enlarges, pressing on the urethra,

00:00:19.280 --> 00:00:23.360
causing problematic symptoms such as
difficulty urinating, a weak stream,

00:00:23.880 --> 00:00:26.560
incomplete bladder emptying,
and frequent urination.

00:00:28.200 --> 00:00:32.400
BPH can adversely impact quality of life
and may also lead to bladder,

00:00:32.880 --> 00:00:34.720
urinary tract, or kidney problems.

00:00:36.160 --> 00:00:40.640
BPH becomes increasingly prevalent
with age, affecting over half of men

00:00:40.760 --> 00:00:43.320
in their 50s and most men by their 70s.

00:00:45.320 --> 00:00:48.640
Fucoidan, a unique polysaccharide found
in brown seaweeds,

00:00:49.160 --> 00:00:52.280
offers exciting potential
to support men with this condition.

00:00:53.400 --> 00:00:57.000
Here we present a clinical study designed
to assess the effects of fucoidan

00:00:57.400 --> 00:01:01.960
from the seaweed Undaria pinnatifida
on prostate health in men with BPH.

00:01:03.040 --> 00:01:07.800
The study involved 88 men with clinically
and radiologically confirmed BPH.

00:01:08.640 --> 00:01:12.760
One half of the participants were
administered 1,000 milligrams per day of

00:01:12.840 --> 00:01:15.600
high purity Undaria pinnatifida fucoidan.

00:01:16.360 --> 00:01:18.280
The other half were
administered a placebo.

00:01:19.440 --> 00:01:23.200
The 90-day study included a baseline
assessment followed by clinical

00:01:23.280 --> 00:01:25.200
assessments at 30-day intervals.

00:01:27.200 --> 00:01:31.360
The study utilised a validated assessment
tool, the International Prostate Symptom

00:01:31.440 --> 00:01:35.760
Score, to assess changes in BPH symptoms.

00:01:36.680 --> 00:01:39.640
It also determined if these changes
were clinically significant.

00:01:40.680 --> 00:01:44.440
In addition, the study included a quality
of life assessment based

00:01:44.520 --> 00:01:45.720
on urinary symptoms.

00:01:48.800 --> 00:01:53.800
Fucoidan supplementation resulted in a
significant improvement in BPH symptoms.

00:01:55.040 --> 00:01:57.760
On day 60,
the group taking fucoidan showed

00:01:57.960 --> 00:02:03.160
significant improvement in total IPSS
compared to the group taking the placebo,

00:02:04.120 --> 00:02:05.960
further improving by day 90.

00:02:08.800 --> 00:02:11.560
On day 60,
double the number of participants

00:02:11.640 --> 00:02:14.560
in the fucoidan group achieved
a clinically significant

00:02:14.640 --> 00:02:16.380
improvement compared to the placebo.

00:02:17.560 --> 00:02:21.680
The difference between the fucoidan
and placebo groups remained statistically

00:02:21.760 --> 00:02:23.960
significant through
to the end of the study.

00:02:26.280 --> 00:02:29.480
The study also revealed ongoing
improvements in individual

00:02:29.560 --> 00:02:31.240
symptoms over 90 days.

00:02:32.240 --> 00:02:36.320
Firstly, an improvement in straining,
followed by improvements in emptying,

00:02:36.680 --> 00:02:38.520
frequency, and intermittency.

00:02:39.680 --> 00:02:44.840
And at day 90, improvements in straining,
emptying, frequency and intermittency.

00:02:47.040 --> 00:02:50.880
Fucoidan was also associated
with a significant improvement in quality

00:02:50.960 --> 00:02:54.200
of life due to improvements
in urinary symptoms.

00:02:55.360 --> 00:02:59.960
On day 90, the fucoidan group showed
a statistically significant improvement

00:03:00.400 --> 00:03:05.080
in the mean quality of life score,
while the placebo group showed no change.

00:03:08.000 --> 00:03:11.840
Importantly,
Undaria pinnatifida fucoidan was shown

00:03:11.920 --> 00:03:14.320
to be safe throughout the 90-day period.

00:03:15.600 --> 00:03:18.760
As a research group,
we concluded that fucoidan supplementation

00:03:18.960 --> 00:03:23.760
significantly alleviated BPH symptoms and
improves prostate related quality of life.

00:03:24.320 --> 00:03:28.840
These findings identify high-purity
Undaria pinnatifida fucoidan produced

00:03:28.920 --> 00:03:33.160
by Marinova as a potentially effective
and safe supplement to support BPH.